Alopecia areata is an immune-mediated, nonscarring form of hair loss. A new study using human clinical samples and a mouse model demonstrates that CD8αβ+NKG2D+ T effector memory cells mediate alopecia areata in part through Janus kinase (JAK) signaling and that alopecia areata might be treated with JAK inhibitors.
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Divito, S., Kupper, T. Inhibiting Janus kinases to treat alopecia areata. Nat Med 20, 989–990 (2014). https://doi.org/10.1038/nm.3685
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DOI: https://doi.org/10.1038/nm.3685
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