A new antiviral capacity for matrix metalloproteinase 12 (MMP-12) adds to our expanding understanding of matrix metalloproteinase biology, from matrix remodeling to host defense, in this issue of Nature Medicine (pages 493–502). Marchant et al. show that following viral infection, macrophages secrete MMP-12, which regulates antiviral immunity both as a transcription factor for IκBα, leading to interferon-α (IFN-α) secretion, and later by degrading extracellular IFN-α, resolving inflammation.
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Dandachi, N., Shapiro, S. A protean protease: MMP-12 fights viruses as a protease and a transcription factor. Nat Med 20, 470–472 (2014). https://doi.org/10.1038/nm.3561
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DOI: https://doi.org/10.1038/nm.3561