About the cover

January 2014 Volume 20 No 1

Following transmission by mosquito bite, the Plasmodium parasite infects the liver, where it differentiates and proliferates but is clinically undetectable. In this issue, Maria Mota and her colleagues report that the parasite is nevertheless detected by cells in the liver, triggering an interferon response that restrains the parasite load (p 47). The cover image, courtesy of Peter Liehl, depicts mouse liver cells (red), the Plasmodium parasite (green) and DNA (blue).