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Nature Medicine  2, 976 - 977 (1996)
doi:10.1038/nm0996-976

Bridging the gap in spinal cord regeneration

Martin E. Schwab

Brain Research Institute, University of Zurich August Forel-strasse 1, PO Box 732, 8029 Zurich, Switzerland

Peripheral nerve grafts promote the growth of nerve fibers in severed rat spinal cords.

REFERENCES
  1. Schwab, M.E. & Bartholdi, D. Degeneration and regeneration of axons in the lesioned spinal cord. Physiol. Rev. 76, 319−370 (1996). | PubMed  | ISI | ChemPort |
  2. Cheng, H., Cao, Y. & Olson, L. Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function. Science 273, 510−513 (1996). | PubMed  | ISI | ChemPort |
  3. Bracken, M.B. et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. N. Engl. J. Med. 322, 1405−1411 (1990). | PubMed  | ISI | ChemPort |
  4. Bartholdi, D. & Schwab, M.E. ethylprednis-olone inhibits early inflammation processes but not ischemic cell death after experimental spinal cord lesion in the rat. Brain Res. 672, 177−186 (1995). | Article | PubMed  | ISI | ChemPort |
  5. Schnell, L., Schneider, R., Kolbeck, R., Barde, Y.A. & Schwab, M.E. Neurotrophin-3 enhances sprouting of corticospinal tract during development and after spinal cord lesion. Nature 367, 170−173 (1994). | Article | PubMed  | ISI | ChemPort |
  6. Bregman, B.S. et al. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 378, 498−501 (1995). | Article | PubMed  | ISI | ChemPort |
  7. Keirstead, H.S., Hasan, S.J., Muir, G.D. & Steeves, J.D. Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord. Proc. Natl. Acad. Sci.USA 69, 11664−11668 (1992).
  8. Varga, Z.M., Bandtlow, C.E., Erulkar, S.D., Schwab, M.E. & Nicholls, J.G. The critical period for repair of CNS of neonatal opossum (Monodelphis domestica) in culture: Correlation with development of glial cells, myelin and growth inhibitory molecules. Eur. J. Neurosci. 7, 2119−2129 (1995). | PubMed  | ISI | ChemPort |
  9. Sauve, Y., Sawai, H. & Rasminsky, M. Functional synaptic connections made by regenerated retinal ganglion cell axons in the superior colliculus of adult hamsters. j Neurosci. 15, 665−675 (1995). | PubMed  | ISI | ChemPort |
  10. Thanos, S. Adult retinofugal axons regenerating through peripheral nerve grafts can restore the light-induced pupilloconstriction reflex. Eur. J. Neurosci. 4, 691−699 (1992). | PubMed  | ISI |
  11. Tello, F. La influencia del neurotropismo en la regeneracion de los centros nerviosos. Trab. Lab. Invest. Biol. 9, 123−159 (1911).
  12. Kao, C.C., Bunge, R.P. & Reier, P.J. eds. Spinal Cord Reconstruction. (Raven, New York, 1983).
  13. David, S. & Aguayo, A.J. Axonal elongation into peripheral nervous system bridges after central nervous system injury in adult rats. Science 214, 931−933 (1981). | PubMed  | ISI | ChemPort |
  14. Richardson, P.M., Issa, V.M.K. & Aguayo, A.J. Regeneration of long spinal axons in the rat. J. Neurocytol. 13, 165−182 (1984). | PubMed  | ISI | ChemPort |
  15. Morrissey, T.K., Kleitman, N. & Bunge, R.P., Schwann cells in vitro. II. Myelination of sensory axons following extensive purification and heregulin-induced expansion. J. Neurobiol. 28, 190−201 (1995). | PubMed  | ISI | ChemPort |
  16. Xu, X.M., Guenard, V., Kleitman, N., Aebischer, P. & Bunge, M.B. A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord. Exp. Neurol. 134, 261−272 (1995). | Article | PubMed  | ISI | ChemPort |
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ISSN: 1078-8956
EISSN: 1546-170X
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