Nature Medicine
2, 800 - 803 (1996)
doi:10.1038/nm0796-800
Enhanced expression of PAI−1 in visceral fat: Possible contributor to vascular disease in obeistyIichiro Shimomura1, Tohru Funahasm1, 4, Masahiko Takahashi1, Kazuhisa Maeda1, Kazuaki Kotani1, Tadashi Nakamura1, Shizuya Yamashita1, Masakazu Miura2, Yoji Fukuda3, Kaoru Takemura1, Katsuto Tokunaga1
& Yuji Matsuzawa1
1Second Department of Internal Medicine, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565, Japan
2Mitsubishi Kagaku Bioclinical Laboratories, 3-30-1 Shimura, Itabashi-ku, Tokyo 174, Japan
3Otsuka Assay Laboratories, 224-18 Kawauchi-cho, Hiraishi, Tokushima, Japan.
4Correspondence should be addressed to T.F. The presence of obesity increases the risk of thrombotic vascular diseases. The role of fat accumulation and its effect on plasminogen activator inhibitor−1 (PAI−1) levels was investigated in humans and animals. Plasma PAI−1 levels were closely correlated with visceral fat area but not with subcutaneous fat area in human subjects. PAI−1 mRNA was detected in both types of fat tissue in obese rats but increased only in visceral fat during the development of obesity. These data suggest that an enhanced expression of the PAI−1 gene in visceral fat may increase plasma levels and may have a role in the development of vascular disease in visceral obesity.
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