Nature Medicine
2, 751 - 752 (1996)
doi:10.1038/nm0796-751
Progress towards a vaccine to prevent sexual transmission of HIVChristopher J. Miller1
& Jerry R. Mcghee2
1California Regional Primate Research Center, University of California Davis, Davis, California 95616, USA
2Mucosal Immunization Research Group, Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA Immunization with subunit antigens prevents rectal transmission of SIV in monkeys (pages 767−775).
REFERENCES
- Marthas, M. et al. Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against intravenous and intravaginal challenge. in Vaccines 1992 (ed. Brown, F., Chanock, R.M., Ginsberg, H.S. & Lerner, R.A.) 117−122 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1992).
- Miller, C.J., Alexander, N.J., Vogel, P., Anderson, J. & Marx, P.A. Mechanism of genital transmission of SIV: A hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques. J. Med. Primatol. 21, 64−68 (1992). | PubMed | ISI | ChemPort |
- Miller, C.J., McGhee, J.R. & Gardner, M.B. Mucosal immunity, HIV transmission and AIDS. Lab. Invest. 68, 129−145 (1992). | ISI |
- Clerici, M. et al. T-cell proliferation to subinfectious SIV correlates with lack of infection after challenge of macaques. AIDS 8, 1391−1395 (1994). | PubMed | ISI | ChemPort |
- Cranage, M.P. et al. Intrarectal challenge of macaques vaccinated with formalin-inactivated simian immunodeficiency virus. Lancet 339, 273−274 (1992). | Article | PubMed | ISI | ChemPort |
- Lehner, T. et al. Protective mucosal immunity elicited by targeted lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nature Med. 2, 767−775 (1996). | Article | PubMed | ISI | ChemPort |
- Thapar, M.A., Parr, E.L. & Parr, M.B. Secretory immune responses in mouse vaginal fluid after pelvic, parenteral or vaginal immunization. Immunology 70, 121−125 (1990). | PubMed | ISI | ChemPort |
- Moore, J.P. et al. Inter- and intraclade neutralization of human immunodeficiency virus type 1: Genetic clades do not correspond to neutralization serotypes but partially correspond to gp120 antigenic serotypes. J. Virol. 70, 427−444 (1996). | PubMed | ISI | ChemPort |
- Brinchmann, J.E., Gaudernack, G. & Vartdal, F. CD8+ T cells inhibit HIV replication in naturally infected CD4+ T cells. J. Immunol. 144, 2961−2966 (1990). | PubMed | ISI | ChemPort |
- Copeland, K.F.T., McKay, P.J. & Rosenthal, K.L. Suppression of activation of the human immunodeficiency virus long terminal repeat by CD8+ T cells is not lentivirus specific. AIDS Res. Hum. Retrovir. 11, 1321−1326 (1995). | PubMed | ISI | ChemPort |
- Otsyula, M.G. et al. Fetal or neonatal infection with attenuated simian immunodeficiency virus results in protective immunity against oral challenge with pathogenic SIVmac251. Virology (in the press).
- Lohman, B.L., Miller, C.J. & McChesney, M.B. Antiviral cytotoxic T lymphocytes in the vaginal mucosa of simian immunodeficiency virus-infected rhesus macaques. J. Immunol. 155, 5855−5860 (1995). | PubMed | ISI | ChemPort |
|
