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Nature Medicine  2, 635 - 636 (1996)
doi:10.1038/nm0696-635

Pyrazinamide — on the antituberculosis drug frontline

Denis A. Mitchison

Department of Medical Microbiology, St George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK

Finding the gene responsible for activating pyrazinamide opens the door to rapid testing for drug resistance (pages 662−667).

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  2. McDermott, W. & Tompsett, R. Activation of pyrazinamide and nicotinamide in acidic environments in vitro. Am. Rev. Tuberc. 70, 748−754 (1954). | PubMed  | ISI | ChemPort |
  3. McCune, R.M., Tompsett, R. & McDermott, W. The fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique. J. Exp. Med. 104, 763−803 (1956). | PubMed  | ISI | ChemPort |
  4. Mitchison, D.A. The action of antituberculosis drugs in short-course chemotherapy. Tubercle 66, 219−225 (1985). | Article | PubMed  | ISI | ChemPort |
  5. Konno, K., Feldmann, F.M. & McDermott, W. Pyrazinamide susceptibility and amidase activity of tubercle bacilli. Am. Rev. Respir. Dis. 95, 461−469 (1967). | PubMed  | ISI | ChemPort |
  6. Cynamon, M.H. et al. Pyrazinoic acid esters with broad spectrum in vitro anti-mycobacterial activity. J. Med. Chem. 38, 3902−3907 (1995). | PubMed  | ISI | ChemPort |
  7. Crowle, A.J., Dahl, R., Ross, E. & May, M.H. Evidence that vesicles containing living, virulent Mycobacterium tuberculosis or Mycobacterium avium in cultured human macrophages are not acidic. Infect. Immun. 59, 1823−1831 (1991). | PubMed  | ISI | ChemPort |
  8. Scorpio, A. & Zhang, Y. Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to antituberculous drug pyrazinamide in tubercle bacillus. Nature Med. 2, 662−667 (1996). | Article | PubMed  | ISI | ChemPort |
  9. Brander, E. A simple way of detecting pyrazinamide resistance. Tubercle, 53, 128−131 (1972). | Article | PubMed  | ChemPort |
  10. Cole, S.T. Mycobacterium tuberculosis: Drug resistance mechanisms. Trends Microbiol. 2, 411−415 (1994). | Article | PubMed  | ChemPort |
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ISSN: 1078-8956
EISSN: 1546-170X
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