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Nature Medicine  2, 630 - 631 (1996)
doi:10.1038/nm0696-630

Microsatellite instability: The mutator that mutates the other mutator

Manuel Perucho

The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA

Microsatellite mutations are useful markers of both tumor clonality and genomic instability but the origin of the mutator mutations responsible is still not well understood (pages 676−681).

REFERENCES
  1. Streisinger, G. et al. Frameshift mutations and the genetic code. Cold Spring Harbor Symp. Quant. Biol. 31, 77−84 (1966). | PubMed  | ISI | ChemPort |
  2. Marra, G. & Boland, C.R. Hereditary nonpolyposis colorectal cancer (HNPCC): The syndrome, the genes, and historical perspectives. J. Natl. Cancer Institute 87, 1114−1125 (1995). | Article | ChemPort |
  3. Ionov, Y., Peinado, M.A., Malkhosyan, S., Shibata, D. & Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363, 558−561 (1993). | Article | PubMed  | ISI | ChemPort |
  4. Loeb, L.A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51, 3075−3079 (1991). | PubMed  | ISI | ChemPort |
  5. Shibata, D., Navidi, W., Salovaara, R., Li, Z-H. & Aaltonen, L.A. Somatic microsatellite mutations as molecular tumor clocks. Nature Med. 2, 676−681 (1996). | Article | PubMed  | ISI | ChemPort |
  6. Shibata, D., Peinado, M.A., Ionov, Y., Malkhosyan, S. & Perucho, M. Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nature Genet. 6, 273−281 (1994). | PubMed  | ISI | ChemPort |
  7. Markowitz, S.J. et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268, 1336−1338 (1995). | PubMed  | ISI | ChemPort |
  8. Knudson, A.G. Hereditary cancer, oncogenes and antioncogenes. Cancer Res. 45, 1437−1443 (1985). | PubMed  | ISI | ChemPort |
  9. Perucho, M. et al. Defects in replication fidelity of simple repeated sequences reveal a new mutator mechanism for oncogenesis. Cold Spring Harbor Symps. Quant. Biol. 59, 339−348 (1994). | ChemPort |
  10. Fearon, E.R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759−767 (1990). | Article | PubMed  | ISI | ChemPort |
  11. Casares, S., Ionov, Y., Ge, H.-Y., Stanbridge, E. & Perucho, M. The microsatellite mutator phenotype of colon cancer cells is often recessive, Oncogene 11, 2303−2310 (1995). | PubMed  | ISI | ChemPort |
  12. Nowell, P. The clonal evolution of tumor cell populations. Science 194, 23−28 (1976). | PubMed  | ISI | ChemPort |
  13. de Wind, N., Dekker, M., Berns, A., Radman, M. & te Riele, H. Inactivation of the mouse MSH2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82, 321−330 (1995). | PubMed  | ChemPort |
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ISSN: 1078-8956
EISSN: 1546-170X
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