Nature Medicine
2, 609 - 610 (1996)
doi:10.1038/nm0696-609
A role for GAPDH in apoptosis and neurodegenerationDe-Maw Chuang1
& Ryoichi Ishitani2
1Section of Molecular Neurobiology Biological Psychiatry Branch National Institute of Mental Health NIH, Building 10, Room 3N212 Bethesda, Maryland 20892-1272, USA
2Group on Cellular Neurobiology Josai University Sakado, Saitama 350-02, Japan
REFERENCES
- Burke, J.R. et al. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nature Med. 2, 347−350 (1996). | Article | PubMed | ISI | ChemPort |
- Ishitani, R. et al. Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture. J. Neurochem. 66, 928−935 (1996). | PubMed | ISI | ChemPort |
- Ishitani, R. et al. An antisense oligodeoxynucleotide to glyceraldehyde-3-phosphate dehydrogenase blocks age-induced apoptosis of mature cerebro-cortical neurons in culture. J. Pharmacol. Exp. Ther. (in the press).
- Portera-Cailliau, C., Hedreen, J.C., Price, D.L. & Koliatsos, V.E. Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models. J. Neurosci. 15, 3775−3787 (1995). | PubMed | ChemPort |
- Sunaga, K., Takahashi, H., Chuang, D.-M. & Ishitani, R. Glyceraldehyde-3-phosphate dehydrogenase is over-expressed during apoptotic death of neuronal cultures and is recognized by a monoclonal antibody against amyloid plaques from Alzheimer's brain. Neurosci. Lett. 200, 133−136 (1995). | Article | PubMed | ISI | ChemPort |
- Stott, K., Blackburn, J.M., Butler, P.J.G. & Perutz, M. Incorporation of glutamine repeats makes protein oligomerize: Implications for neurodegenerative diseases. Proc. Natl. Acad. Sci. USA 92, 6509−6513 (1995). | PubMed | ChemPort |
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