Nature Medicine
2, 400 - 401 (1996)
doi:10.1038/nm0496-400
Toward trophic treatment in parkinsonism: A primate stepLars OlsonDepartment of Neuroscience, Karolinska Institute, Stockholm, S-171 77, Sweden GDNF delivery to the brain decreases cardinal symptoms in a monkey model of Parkinson's disease. REFERENCES
- Lindsay, R.B. Neuron saving schemes. Nature 373, 289−290 (1995). | Article | PubMed | ISI | ChemPort |
- Lin, L.-F. H., Doherty, D.H., Lile, J.D., Bektesh. S. & Collins, F. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopanimergic neurons. Science 260, 1130−1132 (1993). | PubMed | ISI | ChemPort |
- Strömberg, I. et al. Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp. Neurol. 124, 401−412 (1993). | Article | PubMed | ISI |
- Tomac, A. et al. Protection and repair of the nigrostriatal dopaminegic system by GDNF in vivo. Nature 373, 335−339 (1994). | Article | ISI |
- Beck, K.D. et al. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373, 339−341 (1995). | Article | PubMed | ISI | ChemPort |
- Hudson, J. et al. Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in in vivo. Brain Res. Bull. 36, 425−432 (1995). | Article | PubMed | ISI | ChemPort |
- Sauer, H., Rosenblad, C. & Björklund, A. GDNF but not TGF-
3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine-lesion. Proc. Natl. Acad. Sci. USA 92, 8935−8939 (1995). | PubMed | ChemPort |
- Gash, D.M. et al. Functional recovery in GDNF-treated parkinsonian monkeys. Nature 380, 252−255 (1996). | Article | PubMed | ISI | ChemPort |
- Arenas, E., Trupp, M., Åkerud, P. & Ib´ñez, C.F. GDNF prevents degeneration and promotes the phe-notype of brain noradrenergic neurons in vivo. Neuron 15, 1465−1473 (1995). | Article | PubMed | ISI | ChemPort |
- Henderson, C.E. et al. GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266, 1062−1064 (1994). | PubMed | ISI | ChemPort |
- Mount, H.T.J., Dean, D.O., Alberch, J., Dreyfus, C.F. & Black, I.B. Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells. Proc. Natl. Acad. Sci. USA 92, 9092−9096 (1995). | PubMed | ChemPort |
- Ebendal, T., Tomac, A., Hoffer, B.J. & Olson, L. Glial cell line-derived neurotrophic factor stimulates fiber formation and survival in cultured neurons from peripheral autonomic ganglia. J. Neurosci. Res. 40, 276−284 (1995). | PubMed | ISI | ChemPort |
- Buj-Belio, A., Buchman, V.L., Horton, A., Rosenthal, A. & Davies, A.M. GDNF is an age-specific survival factor for sensory and autonomic neurons. Neuron 15, 821−828 (1995). | Article | PubMed |
- Tomac, A. et al. Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult. Proc. Natl. Acad. Sci. USA 92, 9274−8278 (1995). | PubMed |
- Sydow, O. et al. Long-term beneficial effects of adrenal medullary autografts supported by nerve growth factor in Parkinson's disease. Eur. J. Neurol. 2, 1−10 (1995).
- Olson, L. NGF and the treatment of Alzheimer's disease. Exp. Neurol. 124, 5−15 (1993). | Article | PubMed | ISI | ChemPort |
- Gash, D.M. et al. Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys. J. Comp. Neurol. 363, 345−358 (1995). | PubMed | ISI | ChemPort |
- Kotzbauer, P.T., Lampe, P.A., Johnson, E.M. & Milbrandt, J. Neurturin: A novel neurotrophic factor related to GDNF. [Poster replacing Soc. Neurosci. Abstr. 21 (part 1), 544 (1995)].
|