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Nature Medicine  2, 400 - 401 (1996)
doi:10.1038/nm0496-400

Toward trophic treatment in parkinsonism: A primate step

Lars Olson

Department of Neuroscience, Karolinska Institute, Stockholm, S-171 77, Sweden

GDNF delivery to the brain decreases cardinal symptoms in a monkey model of Parkinson's disease.

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  3. Strömberg, I. et al. Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp. Neurol. 124, 401−412 (1993). | Article | PubMed  | ISI |
  4. Tomac, A. et al. Protection and repair of the nigrostriatal dopaminegic system by GDNF in vivo. Nature 373, 335−339 (1994). | Article | ISI |
  5. Beck, K.D. et al. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373, 339−341 (1995). | Article | PubMed  | ISI | ChemPort |
  6. Hudson, J. et al. Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in in vivo. Brain Res. Bull. 36, 425−432 (1995). | Article | PubMed  | ISI | ChemPort |
  7. Sauer, H., Rosenblad, C. & Björklund, A. GDNF but not TGF-beta3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine-lesion. Proc. Natl. Acad. Sci. USA 92, 8935−8939 (1995). | PubMed  | ChemPort |
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  12. Ebendal, T., Tomac, A., Hoffer, B.J. & Olson, L. Glial cell line-derived neurotrophic factor stimulates fiber formation and survival in cultured neurons from peripheral autonomic ganglia. J. Neurosci. Res. 40, 276−284 (1995). | PubMed  | ISI | ChemPort |
  13. Buj-Belio, A., Buchman, V.L., Horton, A., Rosenthal, A. & Davies, A.M. GDNF is an age-specific survival factor for sensory and autonomic neurons. Neuron 15, 821−828 (1995). | Article | PubMed  |
  14. Tomac, A. et al. Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult. Proc. Natl. Acad. Sci. USA 92, 9274−8278 (1995). | PubMed  |
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ISSN: 1078-8956
EISSN: 1546-170X
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