Impaired wound healing in mice with a disrupted plasminogen gene

1. Blasi, F., Vassalli, J.-D. & Danø, K. Urokinase-type plasminogen activator: Proenzyme, plasma membrane binding site and inhibitors. J. Cell Biol. 104, 801−804 (1987). | Article | PubMed  | ChemPort |
2. Saksela, O. & Rifkin, D.B. Cell-associated plasminogen activation: Regulation and physiological functions. Annu. Rev. Cell Biol. 4, 93−126 (1988). | PubMed  | ISI | ChemPort |
3. Vassalli, J.-D. Sappino, A.P. & Belin, D. The plasminogen activator/plasmin system. J. Clin. Invest. 88, 1067−1072 (1991). | PubMed  | ISI | ChemPort |
4. Danø, K. et al. The urokinase receptor. Protein structure and role in plasminogen activation and cancer invasion. Fibrinolysis 8, 189−203 (1994). | ISI |
5. Collen, D. Towards improved thrombolytic therapy. Lancet 342, 34−36 (1993). | Article | PubMed  | ChemPort |
6. Beers, W.H., Strickland, S. & Reich, E. Ovarian plasminogen activator: Relationship to ovulation and hormonal regulation. Cell 6, 387−394 (1975). | Article | PubMed  | ChemPort |
7. Ossowski, L., Biegel, D. & Reich, E. Mammary plasminogen activator: Correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue. Cell 16, 929−940 (1979). | Article | PubMed  | ChemPort |
8. Ny, T., Bjersing, L., Hsueh, A.J.W. & Loskutoff, D.J. Cultured granulosa cells produce two plasminogen activators and an antiactivator, each regulated differently by gonadotropinsa. Endocrinology 116, 1666−1668 (1985). | PubMed  | ChemPort |
9. Sappino, A.P., Huarte, J., Belin, D. & Vassalli, J.-D. Plasminogen activators in tissue remodeling and invasion-messenger RNA localization in mouse ovaries and implanting embryos. J. Cell Biol. 109, 2471−2479 (1989). | Article | PubMed  | ISI | ChemPort |
10. Talhouk, R.S., Bissell, M.J. & Werb, Z. Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution. J. Cell Biol. 118, 1271−1282 (1992). | Article | PubMed  | ISI | ChemPort |
11. Morioka, S., Lazarus, G.S., Baird, J.L. & Jensen, P.L. Migrating keratinocyes express urokinase-type plasminogen activator. J. Invest. Dermatol. 88, 418−423 (1987). | PubMed  | ISI | ChemPort |
12. Grondahl-Hansen, J., Lund, L.R., Ralfkiaer, E., Ottevanger, V. & Dan0, K. Urokinase-and tissue-type plasminogen activators in keratinocytes during wound reepithelialization in vivo. J. Invest. Dermatol. 90, 790−795 (1988). | PubMed  | ISI | ChemPort |
13. Rømer, J. et al. Differential expression of urokinase-type plasminogen activator and its type-1 inhibitor during healing of mouse skin wounds. J. Invest. Dermatol. 97, 803−811 (1991). | PubMed  | ISI |
14. R0mer, J. et al. The receptor for urokinase-type plasminogen activator is expressed by keratinocytes at the leading edge during re-epithelialization of mouse skin wounds. J. Invest. Dermatol. 102, 519−522 (1994). | PubMed  | ISI | ChemPort |
15. Schäfer, B.M., Maier, K., Eickhoff, U., Todd, R.F. & Kramer, M.D. Plasminogen activation in healing human wounds. Am. J. Pathol. 144, 1269−1280 (1994). | PubMed  |
16. Pepper, M.S., Vassalli, J.-D. Montesano, R. & Orci, L. Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells. J. Cell Biol. 105, 2535−2541 (1987). | Article | PubMed  | ISI | ChemPort |
17. Pepper, M.S. et al. Upregulation of urokinase receptor expression on migrating endothelial cells. J. Cell Biol. 122, 673−684 (1993). | Article | PubMed  | ChemPort |
18. Danø, K. et al. Plasminogen activators, tissue degradation, and cancer. Adv. Cancer Res. 44, 139−266 (1985). | PubMed  | ISI | ChemPort |
19. Ossowski, L. Plasminogen activator dependent pathways in the dissemination of human tumor cells in the chick embryo. Cell 52, 321−328 (1988). | PubMed  | ChemPort |
20. Liotta, L.A., Steeg, P.S. & Stetler-Stevenson, W.G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64, 327−336 (1991). | PubMed  | ISI | ChemPort |
21. Pyke, C. et al. Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocar-cinomas. Am. J. Pathol. 138, 1059−1067 (1991). | PubMed  | ISI | ChemPort |
22. Crowley, C.W. et al. Prevention of metastasis by inhibition of the urokinase receptor. Proc. Natl. Acad. Sci. USA 90, 5021−5025 (1993). | PubMed  | ChemPort |
23. Heiss, M.M. et al. Individual development and uPA-receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer. Nature Med. 1, 1035−39 (1995). | Article | PubMed  | ISI | ChemPort |
24. Bugge, T.H., Flick, M.J., Daugherty, C.C. & Degen, J.L. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev. 9, 794−807 (1995). | PubMed  | ISI | ChemPort |
25. Clark, R.A.F. & Henson, P.M., eds. The Molecular and Cellular Biology of Wound Repair (Plenum, New York, 1988).
26. Donaldson, D.J. & Mahan, J.T. Keratinocyte migration and the extracellular matrix. J. Invest. Dermatol. 90, 623−628 (1988). | PubMed  | ChemPort |
27. Unkeless, J.C., Gordon, S. & Reich, E. Secretion of plasminogen activator by stimulated macrophages. J. Exp. Med. 139, 834−850 (1974). | Article | PubMed  | ChemPort |
28. Heiple, J.M. & Ossowski, L. Human neutrophil plasminogen activator is localized in specific granules and is translocated to the cell surface by exocytosis. J. Exp. Med. 164, 826−840 (1986). | Article | PubMed  | ChemPort |
29. Pöllanen, J., Hedman, K., Nielsen, L.S., Danø, K. & Vaheri, A. Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts. J. Cell Biol. 106, 87−95 (1988). | Article | PubMed  | ISI |
30. Vassalli, J.-D. Wohlwend, A. & Belin, D. Urokinase-catalyzed plasminogen activation at the monocyte/macrophage cell surface: A localized and regulated proteolytic system. Cur. Top. Microbiol. Immunol. 181, 65−86 (1992). | ChemPort |
31. Salo, T., Makela, M., Kylmaniemi, M., Autio-Harmainen, H. & Larjava, H. Expression of matrix metalloproteinase-2 and -9 during early human wound healing. Lab. Invest. 70, 176−182 (1994). | PubMed  | ISI | ChemPort |
32. Inoue, M., Kratz, G., Haegerstrand, A. & Stahle-Backdahl, M. Collagenase expression is rapidly induced in wound-edge keratinocytes after acute injury in human skin, persists during healing, and stops at re-epithelialization. J. Invest. Dermatol. 104, 479−483 (1995). | PubMed  | ChemPort |
33. Saarialho-Kere, U.K. et al. Interstitial collagenase is expressed by keratinocytes that are actively involved in reepithelialization in blistering skin disease. J. Invest. Dermatol. 104, 982−988 (1995). | PubMed  | ChemPort |
34. Werb, Z., Mainardi, C., Vater, C.A. & Harris, E.D. Endogenous activation of latent collagenase by rheumatoid synovial cells. N. Engl. J. Med. 296, 1017−1023 (1977). | PubMed  | ISI | ChemPort |
35. Mignatti, P. & Rifkin, D.B. Biology and biochemistry of proteinases in tumor invasion. Physiol. Rev. 73, 161−195 (1993). | PubMed  | ISI | ChemPort |
36. Grainger, D.J., Kemp, P.R., Liu, A.C., Lawn, R.M. & Metcalfe, J.C. Activation of transforming growth factor-beta is inhibited in transgenic apolipoprotein(a) mice. Nature 370, 460−462 (1994). | Article | PubMed  | ISI | ChemPort |
37. Suh, T. et al. Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes Dev. 9, 2020−2033 (1995). | PubMed  | ISI | ChemPort |
38. Carmeliet, P. et al. Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368, 419−424 (1994). | Article | PubMed  | ISI | ChemPort |
39. Dvorak, H.F. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650−1659 (1986). | ChemPort |
40. Prendergast, G.C., Diamond, L.E., Dahl, D. & Cole, M.D. The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1. Mol. Cell. Biol. 10, 1265−1269 (1990). | PubMed  | ISI | ChemPort |

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