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Nature Medicine  2, 284 - 285 (1996)
doi:10.1038/nm0396-284

Cuts and scrapes? Plasmin heals!

Jean-Dominique Vassalli1 & Jean-Hilaire Saurat1, *

  1Department of Morphology, University of Geneva Medical School 1211, Geneva 4, Switzerland

  *Department of Dermatology, University of Geneva Medical School 1211, Geneva 4, Switzerland

The healing of skin wounds is severely affected in mice with a targeted disruption of the plasminogen gene (pages 287−292).

REFERENCES
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  2. Vassalli, J.-D., Sappino, A.P. & Belin, D. The plasminogen activator/plasmin system. J. Clin. Invest. 88, 1067−1072 (1991). | PubMed  | ISI | ChemPort |
  3. Carmeliet, P. et al. Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368, 419−424 (1994). | Article | PubMed  | ISI | ChemPort |
  4. Bugge, T.H., Flick, M.J., Daugherty, C.C. & Degen, J.L. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev. 9, 794−807 (1995). | PubMed  | ISI | ChemPort |
  5. Morioka, S., Lazarus, G.S., Baird, J.L. & Jensen, P.L. Migrating keratinocytes express urokinase-type plasminogen activator. J. Invest. Dermatol. 88, 418−423 (1987). | PubMed  | ISI | ChemPort |
  6. Grøndahl-Hansen, J., Lund, L.R., Ralfkiaer, E., Ottevanger, V. & Danønm>, K. Urokinase-and tissue-type plasminogen activators in keratinocytes during wound reepithelialization in vivo. J. Invest. Dermatol. 90, 790−795 (1988). | PubMed  | ISI | ChemPort |
  7. Rømer, J. et al. The receptor for urokinase-type plasminogen activator is expressed by keratinocytes at the leading edge during re-epithelialization of mouse skin wounds. J. Invest. Dermatol. 102, 519−522 (1994). | PubMed  | ISI | ChemPort |
  8. Werner, S. et al. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Science 266, 819−822 (1994). | PubMed  | ISI | ChemPort |
  9. Carmeliet, P. & Collen, D. Gene targeting and gene transfer studies of the plasminogen/plas-min system: Implications in thrombosis, hemo-stasis, neointima formation, and atherosclerosis. FASEB J. 9, 934−938 (1995). | PubMed  | ISI | ChemPort |
  10. Westerhof, W., van Ginkel, C.J.W., Cohen, E.B. & Mekkes, J.R. Prospective randomized study comparing the debriding effect of krill enzymes and a non-enzymatic treatment in venous leg ulcers. Dermatologica 181, 293−297 (1990). | PubMed  | ISI | ChemPort |
  11. Mulder, G., Jones, R., Cederholm-Williams, S., Cherry, G. & Ryan, T. Fibrin cuff lysis in chronic venous ulcers treated with a hydrocolloid dressing. Int. J. Dermatol. 32, 304−306 (1993). | PubMed  | ISI | ChemPort |
  12. Dvorak, H.F., Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650−1659 (1986). | PubMed  | ISI | ChemPort |
  13. Sappino, A.P. et al. Differential protease expression by cutaneous squamous and basal Cell carcinomas. J. Clin. Invest. 88, 1073−1079 (1991). | PubMed  | ISI | ChemPort |
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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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