Nature Medicine
2, 1313 - 1314 (1996)
doi:10.1038/nm1296-1313
Aminoglycoside excitement silences hearingPatrik Ernfors1
& Barbara Canlon2
1Departments of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
2Departments of Physiology and Pharmacology, Karolinska Institute, 171 77 Stockholm, Sweden NMDA receptor antagonists attenuate hearing loss induced by the excitotoxic action of aminoglycoside antibiotics (page 1338−1343).
REFERENCES
- Hawkins, J.E. Drug Ototoxicity. in Handbook of Sensory Physiology (ed. Keidel, W.D. & Neff, W.D.) 707−748 (Springer, Berlin, 1976).
- Basile, A.S. et al. N-methyl-D-aspartate antagonists limit aminoglycoside-induced Ototoxicity. Nature Med. 2, 1338−1343 (1996). | Article | PubMed | ISI | ChemPort |
- Pullan, L.M., Stumpo, R.J., Powel, R.J., Paschetto, K.A. & Britt, M. Neomycin is an agonist at a polyamine site on the N-methyl-D-aspartate receptor. J. Neurochem. 59, 2087−2093 (1992). | PubMed | ISI | ChemPort |
- Muir, K.W. & Lees, K.R. Clinical experience with excitatory amino acid antagonist drugs. Stroke 26, 503−513 (1995). | PubMed | ISI | ChemPort |
- Niedzielski, A.S. & Wenthold, R.J. Expression of AMPA, kainate, and NMDA receptor subunits in cochlear and vestibular ganglia. J. Neurosci. 15, 2338−2353 (1995). | PubMed | ISI | ChemPort |
- Colvin, J.S., Bohne, B.A., Harding, G.W., McEwen, D.G. & Ornitz, D.M. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nature Genet. 12, 390−397 (1996). | Article | PubMed | ISI | ChemPort |
- Pirvola, U. et al. The site of action of neuronal acidic fibroblast growth factor is the organ of Corti of the rat cochlea. Proc. Natl. Acad. Sci. USA. 92, 9269−9273 (1995). | PubMed | ChemPort |
- Vassbotn, F.S., Ostman, A., Siegbahn, A., Holmsen, H. & Heldin, C.H. Neomycin is a platelet-derived growth factor (PDGF) antagonist that allows discrimination of PDGF alpha-and beta-receptor signals in cells expressing both receptor types. J. Biol. Chem. 267, 15635−15641 (1992). | PubMed | ISI | ChemPort |
- Ernfors, P., Merlio, J.-P. & Persson, H. Cells expressing mRNA for neurotrophins and their receptors during embryonic rat development. Eur. J. Neurosci. 4, 1140−1158 (1992). | PubMed | ISI |
- Pirvola, U. et al. Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia. Proc. Natl. Acad. Sci. USA 89, 9915−9919 (1992). | PubMed | ChemPort |
- Ernfors, P., Van De Water, T.R., Loring, J. & Jaenisch, R. Complementary roles of BDNF and NT-3 in auditory and vestibular development. Neuron 14, 1153−1164 (1995). | PubMed | ISI | ChemPort |
- Ernfors, P., Duan, M.D., ElShamy, W.M. & Canlon, B. Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3. Nat. Med. 2, 463−467 (1996). | Article | PubMed | ISI | ChemPort |
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