Journal home
Advance online publication
Current issue
Archive
Press releases
Supplements
Focuses
Guide to authors
Online submissionOnline submission
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
Reprints and permissions
About this site
For librarians
 
NPG Resources
Nature
Nature Reviews
Nature Immunology
Nature Cell Biology
Nature Genetics
news@nature.com
Nature Conferences
Dissect Medicine
NPG Subject areas
Biotechnology
Cancer
Chemistry
Clinical Medicine
Dentistry
Development
Drug Discovery
Earth Sciences
Evolution & Ecology
Genetics
Immunology
Materials Science
Medical Research
Microbiology
Molecular Cell Biology
Neuroscience
Pharmacology
Physics
Browse all publications
News and Views
Nature Medicine  2, 1311 - 1312 (1996)
doi:10.1038/nm1296-1311

From Th1 to Th2: Diabetes immunotherapy shifts gears

Michele Solimena1 & Pietro De Camilli2

  1Department of Internal Medicine, Section of Endocrinology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA

  2Department of Cell Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA

Autoantigen administration in an animal model of diabetes prevents development of the disease even after insulitis is established (pages 1348−1353).

REFERENCES
  1. Tian, J. et al. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nature Med. 2, 1348−1353 (1996). | Article | PubMed  | ISI | ChemPort |
  2. Harrison, L.C. Antigen-specific therapy for autoimmune disease: Prospects for the prevention of insulin-dependent diabetes. Molec. Med. 1, 722−727 (1995). | ISI | ChemPort |
  3. Verge, C.F. et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512/IA-2 autoantibodies. Diabetes 45, 926−933 (1996). | PubMed  | ISI | ChemPort |
  4. Tyden, G., Reinholt, F.P., Sundkvist, G. & Bolinder, J. Recurrence of autoimmune diabetes mellitus in recipients of cadaveric pancreatic grafts. N. Eng. J. Med. 335, 860−863 (1996). | Article | ISI | ChemPort |
  5. Solimena, M. & De Camilli, P. Autoimmunity to glutamic acid decarboxylase (GAD) in stiff-man syndrome and insulin-dependent diabetes mellitus. Trends Neurosci. 14, 452−457 (1991). | Article | PubMed  | ISI | ChemPort |
  6. Kaufman, D.L. et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366, 69−72 (1993). | Article | PubMed  | ISI | ChemPort |
  7. Tisch, R. et al. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366, 72−75 (1993). | Article | PubMed  | ISI | ChemPort |
  8. Elliott, J.F. et al. Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune disease in NOD mice. Diabetes 43, 1494−1499 (1994). | PubMed  | ISI | ChemPort |
  9. Petersen, J.S. et al. Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in NOD mice. Diabetes 43, 1478−1484 (1994). | PubMed  | ISI | ChemPort |
  10. Pleau, J.M., Fernandez-Saravia, F., Esling, A., Homo-Delarche, F. & Dardenne, M. Prevention of autoimmune diabetes in nonobese diabetic female mice by treatment with recombinant glutamic acid decarboxylase (GAD 65). Clin. Immunol. Immunopath. 76, 90−95 (1995). | Article | ISI | ChemPort |
  11. Forsthuber, T., Yip, H.C. & Lehmann, P.V. Induction of TH1 and TH2 immunity in neonatal mice. Science 271, 1728−1730 (1996). | PubMed  | ISI | ChemPort |
  12. Tian, J. et al. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J. exp. Med. 183, 1561−1567 (1996). | Article | PubMed  | ISI | ChemPort |
  13. Elias, D. & Cohen, I.R. Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277. Lancet 343, 704−706 (1994). | Article | PubMed  | ISI | ChemPort |
  14. Keller, R.J., Eisenbarth, G.S. & Jackson, R.A. Insulin prophylaxis in individuals at high risk of type I diabetes. Lancet 341, 927−928 (1993). | Article | PubMed  | ISI | ChemPort |
  15. Haskins, K. & Wegmann, D. Diabetogenic T-cell clones. Diabetes 45, 1299−1305 (1996). | PubMed  | ISI | ChemPort |
  16. Katz, J.D., Benoist, C. & Mathis, D. T helper cell subsets in insulin-dependent diabetes. Science 268, 1185−1188 (1995). | PubMed  | ISI | ChemPort |
  17. Serreze, D.V., Leiter, E.H., Christianson, G.J., Greiner, D. & Roopenian, D.C. Major histocompatibility complex class I-deficient NOD B2-null mice are diabetes and insulitis resistant. Diabetes 43, 505−509 (1994). | PubMed  | ISI | ChemPort |
  18. Wicker, L.S. et al. Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes 43, 505−509 (1994). | PubMed  | ISI | ChemPort |
  19. Wong, F.S., Visintin, I., Wen, L., Flavell, R.A. & Janeway, C.A. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med. 183, 67−76 (1996). | Article | PubMed  | ISI | ChemPort |
 Top
 Top
References
Previous | Next
Table of contents
Download PDFDownload PDF
Send to a friendSend to a friend
Save this linkSave this link

Open Innovation Challenges

naturejobs

References
Export citation
Export references
natureproducts

Search buyers guide:

 
ADVERTISEMENT
 
Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
Journal home | Advance online publication | Current issue | Archive | Press releases | Supplements | Focuses | For authors | Online submission | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | Reprints and permissions | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©1996 Nature Publishing Group | Privacy policy