Nature Medicine
2, 1308 - 1310 (1996)
doi:10.1038/nm1296-1308
Hedgehogs in the clinicAndrew P. McMahon1
& Pao-Tien Chuang1
1Department of Molecular and Cellular Biology The Biolabs 16 Divinity Avenue Harvard University Cambridge, Massachusetts 02138, USA Components of the hedgehog signaling pathways play key roles during embryonic development and in several human diseases. REFERENCES
- Nusslein-Volhard, C. & Wieschaus, E. Mutations affecting segment number and polarity in Drosophila. Nature 287, 795−801 (1980). | PubMed | ISI | ChemPort |
- Echelard, Y. et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417−1430 (1993). | PubMed | ISI | ChemPort |
- Bitgood, M.J., Shen, L. & McMahon, A.P. Sertoli cell signaling by Desert hedgehog regulates the male germ line. Curr. Biol. 6, 298−304 (1996). | Article | PubMed | ISI | ChemPort |
- Vortkamp, A. et al. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 613−622 (1996). | PubMed | ISI | ChemPort |
- Chiang, C. et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407−413 (1996). | Article | PubMed | ISI | ChemPort |
- Belloni, E. et al. Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nature Genet. 14, 353−356 (1996). | Article | PubMed | ISI | ChemPort |
- Roessler, E. et al. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nature Genet. 14, 357−360 (1996). | Article | PubMed | ISI | ChemPort |
- Porter, J.A., Young, K.E. & Beachy, P.A. Cholesterol modification of hedgehog signaling proteins in animal development. Science 274, 255−259 (1996). | Article | PubMed | ISI | ChemPort |
- Johnson, R.L. et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272, 1668−1671 (1996). | PubMed | ISI | ChemPort |
- Hahn, H. et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85, 841−851 (1996). | Article | PubMed | ISI | ChemPort |
- Chen, Y. & Struhl, G. Dual roles for patched in sequestering and transducing hedgehog. Cell 87, 553−563 (1996). | Article | PubMed | ISI | ChemPort |
- Stone, D.M. et al. Vertebrate homologues of patched and smoothened compose a receptor for sonic hedgehog. Nature 384, 129−154 (1996). | Article | PubMed | ISI | ChemPort |
- Marigo, V., Davey, R.A., Zuo, Y., Cunningham, J.M. & Tabin, C.J. Biochemical evidence that patched is the hedgehog receptor. Nature 384, 176−179 (1996). | Article | PubMed | ISI | ChemPort |
- Hammerschmidt, M., Brook, A. & McMahon, A.P. The world according to hedgehog. Trends Genet, (in the press).
- Rong, P.M., Teillet, M.A., Ziller, C. & Le Douarin, N.M. The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation. Development 115, 657−672 (1992). | PubMed | ISI | ChemPort |
- Cohen, M.M. Perspectives on holoprosencephaly: Part I. Epidemiology, genetics, and syndromology. Teratology 40, 211−235 (1989). | PubMed | ISI |
- Roux, C. Arch. Fr. Pediatr. 21, 451 (1964). | PubMed | ChemPort |
- Marigo, V. et al. Cloning, expression, and chromosomal location of SHH and IHH: Two human homologues of the Drosophila segment polarity gene hedgehog. Genomics 28, 44−51 (1995). | Article | PubMed | ISI | ChemPort |
- Porter, J.A. et al. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 374, 363−366 (1995). | Article | PubMed | ISI | ChemPort |
- Ericson, J., Morton, S., Kawakami, A., Roelink, H. & Jessell, T.M. Two critical periods of sonic hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661−673 (1996). | Article | PubMed | ISI | ChemPort |
- Tsukurov, O. et al. A complex bilateral polysyndactyly disease locus maps to chromosome 7q36. Nature Genet. 6, 282−286 (1994). | Article | PubMed | ISI | ChemPort |
- Maden, M. Developmental biology. The limb bud − Part two. Nature 371, 560−561 (1994). | Article | PubMed | ISI | ChemPort |
- Bitgood, M.J. & McMahon, A.P. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 172, 126−138 (1995). | Article | PubMed | ISI | ChemPort |
- Perrimon, N. Serpentine proteins slither into the wingless and hedgehog fields. Cell 86, 513−516 (1996). | Article | PubMed | ISI | ChemPort |
- Ingham, P.W. Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo. Nature 366, 560−562 (1993). | Article | PubMed | ISI | ChemPort |
- Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M. & Hooper, J.E., The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86, 221−232 (1996). | Article | PubMed | ISI | ChemPort |
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