Sweet news for hypoglycemic babies

Pancreatic -cells from PHHI patients lack functional K_ATP channels (pages 1344−1347).

1. Thomas, P.M. et al. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science 268, 425−429 (1995).
2. Kane, C. et al. Loss of functional KATI, channels in -cells causes persistent hyperinsulinemic hypoglycemia of infancy. Nature Med. 2, 1344−1347 (1996). | Article | PubMed  | ISI | ChemPort |
3. Ashcroft, F. M. & Rorsman, P. Electrophysiology of the pancreatic -cell. Prog. Biophys. Mol. Biol. 54, 87−143 (1989). | Article | PubMed  | ChemPort |
4. Ashcroft, F.M. & Ashcroft, S.J.H. The sulphonylurea receptor. Biochem. Biophys. Acta 1175, 45−59 (1992). | Article | PubMed  |
5. Dunne, M.J., Harding, E., Jaggar, J.H., Ayton, B.J. & Squires, P.E. Endogenous and chemical activators of ATP-regulated potassium channels in insulin-secreting cells: Possible mechanisms and physiological significance. in Frontiers of Insulin Secretion and Pancreatic -Cell Research. (ed. Flatt, P. & Lenzen, S.) 153−159 (Smith Gordon, London,1993).
6. Lindley, K.J. et al. Ionic control of -cell function in nesidioblastosis. A possible herapeutic role for calcium channel blockade. Arch. Dis. Child.. 74, 373−378 (1996). | PubMed  | ISI | ChemPort |
7. Aguilar-Bryan, L. et al. Cloning of the -cell high-affinity sulfonylurea receptor: A regulator of insulin secretion. Science 268, 423−425 (1995). | PubMed  | ChemPort |
8. Inagaki, N. et al. Reconstitution of I_KATP: An inward rectifier subunit plus the sulfonylurea receptor. Science 270, 1166−1169 (1995). | PubMed  | ISI | ChemPort |
9. Sakura, H., Ammala, C., Smith, P.A., Gribble, F.M. & Ashcroft, F.M. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel expressed in pancreatic b cells, brain, heart and skeletal muscle. FEBS Lett. 377, 338−344 (1995). | Article | PubMed  | ISI | ChemPort |
10. Inoue, H. et al. Sequence variants in the sulfonylurea receptor (SUR) gene are associated with non-insulin-dependent diabetes mellitus (NIDDM) in Caucasians. Diabetes 45, 825−831 (1996). | PubMed  | ISI | ChemPort |

	Top

	Top