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Nature Medicine  2, 1195 - 1196 (1996)
doi:10.1038/nm1196-1195

A liquid panacea for failing lungs?

Ronald B. Hirschil

Department of Surgery, University of Michigan Ann Arbor, Michigan 48109-0245, USA

Partial liquid ventilation with perfluorocarbons has clinical potential for improving lung function in patients with respiratory failure.

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  2. Shaffer, T.H., Wolfson, M.R. & Clark, L. Liquid ventilation. Pediatr. Pulmonol. 14, 102−109 (1992). | PubMed  | ISI | ChemPort |
  3. Leach, C.L. et al. Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome. N. Engl. J. Med. 335, 761−767 (1996). | Article | PubMed  | ISI | ChemPort |
  4. Shaffer, T.H. & Moskowitz, G.D. Demand-controlled liquid ventilation of the lungs. J. Appl. Physiol. 36, 208−213 (1974). | PubMed  | ISI | ChemPort |
  5. Fuhrman, B.P., Paczan, P.R. & DeFrancisis, M. Perfluorocarbon-associated gas exchange. Crit. Care Med. 19, 712−722 (1991). | PubMed  | ISI | ChemPort |
  6. Greenspan, J.S., Wolfson, M.R., Rubenstein, S.D. & Shaffer, T.H. Liquid ventilation of human preterm neonates. J. Pediatr. 117, 106−111 (1990). | PubMed  | ISI | ChemPort |
  7. Hirschl, R.B. et al. Liquid ventilation in adults, children and full-term neonates: Preliminary report. Lancet 346, 1201−1202 (1995). | Article | PubMed  | ISI | ChemPort |
  8. Hirschl, R.B. Initial experience with partial liquid ventilation in adult patients with the acute respiratory distress syndrome. JAMA 275, 383−389 (1996). | Article | PubMed  | ISI | ChemPort |
  9. Pranikoff, T., Gauger, P. & Hirschl, R.B. Partial liquid ventilation in newborn patients with congenital diaphragmatic hernia. J. Pediatr. Surg. 31, 613−618 (1996). | PubMed  | ISI | ChemPort |
  10. Toro-Figueroa, L.O. et al. Perflubron partial liquid ventilation (PLV) in children with ARDS: A safety and efficacy pilot study. Crit. Care Med. 24, A150 (1996).
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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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