Nature Medicine
2, 1069 - 1071 (1996)
doi:10.1038/nm1096-1069
Neurotrophin−3 knocks heart off TrkDeepak Srivastava1, 2
& Eric N. Olson2
1Department of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center Dallas, Texas 75235-9148, USA
2Department of Molecular Biology and Oncology University of Texas Southwestern Medical Center Dallas, Texas 75235-9148, USA Heart defects in NT-3 knockout mice implicate this neurotrophin in cardiac development. REFERENCES
- Donovan, M., Hahn, R., Tessarollo, L. & Hempstead, B.L. Neurotrophin-3 is required for mammalian cardiac development: Identification of an essential nonneuronal neurotrophin function. Nature Genet. 14, 210−213 (1996). | PubMed | ISI | ChemPort |
- Snider, W.D. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us. Cell 77, 627−638 (1994). | Article | PubMed | ISI |
- Ernfors, P., Lee, K., Kucera, J. & Jaenisch, R. Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77, 503−512 (1994). | Article | PubMed | ISI | ChemPort |
- Farlnas, I., Jones, K.R., Backus, C., Wang, X. & Reichardt, L.F. Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature 369, 658−661 (1994). | Article | PubMed | ISI | ChemPort |
- Tessarollo, L., Vogel, K.S., Palko, M.E., Reid, S.W. & Parada, L.F. Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons. Proc. Nati. Acad. Sd. USA 91, 11844−11848 (1994). | ChemPort |
- Olson, E.N. & Srivastava, D. Molecular pathways controlling heart development. Science 272, 671−676 (1996). | PubMed | ISI | ChemPort |
- Kirby, M.L. & Waldo, K.L. Role of neural crest in congenital heart disease. Circulation 82, 332−340 (1990). | PubMed | ISI | ChemPort |
- Wilson, D.I., Burn, J., Scambler, P. & Goodship, J. DiGeorge syndrome: Part of CATCH-22. J. Med. Genet. 30, 852−856 (1993). | PubMed | ISI | ChemPort |
- Kurihara, Y. et al. Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J. din. Inv. 96, 293−300 (1995). | ChemPort |
- Kastner, P. Genetic analysis of RXR alpha developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell 78, 987−1003 (1994). | Article | PubMed | ISI | ChemPort |
- Epstein, D.J., Vogan, K.J., Trasler, D.G. & Gros, P. A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the Splotch mouse mutant. Proc. Natl. Acad. Sci. USA 90, 532−536 (1993). | PubMed | ChemPort |
- Kalcheim, C., Carmeli, C. & Rosenthal, A. Neurotrophin-3 is a mitogen for cultured neural crest cells. Proc. Natl. Acad. Sci. USA 89, 1661−1665 (1992). | PubMed | ChemPort |
- Klein, R. et al. Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements. Nature 368, 249−251 (1994). | Article | PubMed | ISI | ChemPort |
- Cserjesi, P. et al. MHox: A mesodermally-restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer. Development 115, 1087−1101 (1992). | PubMed | ISI | ChemPort |
- Guillemot, F. et al. Mammalian achaete-scute homolog-1 is required for the early development of olfactory and autonomic neurons. Cell 75, 463−476 (1993). | Article | PubMed | ISI | ChemPort |
- Srivastava, D., Cserjesi, P. & Olson, E.N. A subclass of bHLH proteins required for cardiac morphogenesis. Science 270, 1995−1999 (1995). | PubMed | ISI | ChemPort |
- Flake, A.W. & Harrison, M.R. Fetal surgery. Annu. Rev. Med. 46, 67−78 (1995). | Article | PubMed | ISI | ChemPort |
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