A signaling cascade is activated in podocytes to induce survival and cope with stress during advanced glomerular disease, a new study shows. The findings may also explain why the immunosuppressor sirolimus, an inhibitor of this pathway, can cause proteinuria in a subset of patients with chronic kidney disease (pages 1288–1296).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Marina Corral Spence
References
Reiser, J. & Sever, S. Annu. Rev. Med. 64, 357–366 (2013).
Canaud, G. et al. Nat. Med. 19, 1288–1296 (2013).
Wei, C. et al. Nat. Med. 14, 55–63 (2008).
Nagase, M. & Fujita, T. Nat. Rev. Nephrol. 9, 86–98 (2013).
Sarbassov, D.D. et al. Mol. Cell 22, 159–168 (2006).
Laplante, M. & Sabatini, D.M. Cell 149, 274–293 (2012).
Huber, T.B. et al. Mol. Cell Biol. 23, 4917–4928 (2003).
Nozaki, S. et al. Cell Signal. 25, 1361–1371 (2013).
Diekmann, F. et al. Transplant. Rev. (Orlando) 26, 27–29 (2012).
Gödel, M. et al. J. Clin. Invest. 121, 2197–2209 (2011).
Kistler, A.D. et al. Kidney Int. 81, 1053–1055 (2012).
Yaddanapudi, S. et al. J. Clin. Invest. 121, 3965–3980 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
J.R. is an inventor on issued and pending patents on new mechanisms and technologies for proteinuric kidney diseases. He stands to gain royalties from the commercialization of these technologies.
Rights and permissions
About this article
Cite this article
Reiser, J. Akt2 relaxes podocytes in chronic kidney disease. Nat Med 19, 1212–1213 (2013). https://doi.org/10.1038/nm.3357
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.3357
