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The dark side of the oxidative force in angiogenesis

Nature Medicine volume 18, pages 1184–1185 (2012)Cite this article

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A new mechanism regulating pathological angiogenesis has been identified that involves the activation of ataxia-telangiectasia mutated (Atm) kinase in response to reactive oxygen species. Importantly, this Atm-dependent pathway is specifically activated in pathological, but not in normal, angiogenesis, suggesting that it could be therapeutically targeted in diseases associated with pathological angiogenesis (pages 1208–1216).

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Figure 1: Under oxidative stress, activated ATM induces angiogenesis.

Katie Vicari

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Authors and Affiliations

  1. Bethany A. Kerr is in the Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis, Cleveland, Ohio, USA.,

    Bethany A Kerr

  2. Tatiana V. Byzova is in the Vascular Biology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio, USA.,

    Tatiana V Byzova

Authors
  1. Bethany A Kerr
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  2. Tatiana V Byzova
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Correspondence to Tatiana V Byzova.

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The authors declare no competing financial interests.

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Kerr, B., Byzova, T. The dark side of the oxidative force in angiogenesis. Nat Med 18, 1184–1185 (2012). https://doi.org/10.1038/nm.2881

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