Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cutting SRC-1 down to size in endometriosis

Nature Medicine volume 18, pages 1016–1018 (2012)Cite this article

Subjects

Endometriosis occurs when estrogen-sensitive endometrial cells that are shed to distal sites manage to attach and survive in a foreign, inflammatory environment. A new study reports a unique interaction between a cleaved form of steroid receptor coactivator 1 (SRC-1) and caspase 8 that blocks apoptosis in endometriotic cells, allowing them to survive (pages 1102–1111).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: SRC-1 in the etiology of endometriosis.

Katie Vicari

References

  1. Nnoaham, K.E. et al. Fertil. Steril. 96, 366–373 (2011).

    Article  Google Scholar 

  2. Bulun, S.E. N. Engl. J. Med. 360, 268–279 (2009).

    Article  CAS  Google Scholar 

  3. Sampson, J.A. Am. J. Obstet. Gynecol. 14, 422–469 (1927).

    Article  Google Scholar 

  4. Giudice, L.C. N. Engl. J. Med. 362, 2389–2398 (2010).

    Article  CAS  Google Scholar 

  5. Nasu, K., Yuge, A., Tsuno, A., Nishida, M. & Narahara, H. Histol. Histopathol. 24, 1181–1192 (2009).

    CAS  Google Scholar 

  6. Han, S.J. et al. Nat. Med. 18, 1102–1111 (2012).

    Article  CAS  Google Scholar 

  7. Gaide Chevronnay, H.P. et al. Biochim. Biophys. Acta 1824, 146–156 (2012).

    Article  CAS  Google Scholar 

  8. Stilley, J.A., Woods-Marshall, R., Sutovsky, M., Sutovsky, P. & Sharpe-Timms, K.L. Biol. Reprod. 80, 649–656 (2009).

    Article  CAS  Google Scholar 

  9. Hansen, K.D. et al. Nat. Genet. 43, 768–775 (2011).

    Article  CAS  Google Scholar 

  10. Braundmeier, A.G. & Fazleabas, A.T. Mol. Hum. Reprod. 15, 577–586 (2009).

    Article  CAS  Google Scholar 

  11. McBryan, J. et al. Cancer Res. 72, 548–559 (2012).

    Article  CAS  Google Scholar 

  12. York, B. & O'Malley, B.W. J. Biol. Chem. 285, 38743–38750 (2010).

    Article  CAS  Google Scholar 

  13. Islimye, M. et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 159, 184–189 (2011).

    Article  CAS  Google Scholar 

  14. Giraudo, E., Inoue, M. & Hanahan, D. J. Clin. Invest. 114, 623–633 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Matthew T. Dyson and Serdar E. Bulun are in the Department of Obstetrics and Gynecology at Feinberg School of Medicine, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA.,

    Matthew T Dyson & Serdar E Bulun

Authors
  1. Matthew T Dyson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Serdar E Bulun
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Serdar E Bulun.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dyson, M., Bulun, S. Cutting SRC-1 down to size in endometriosis. Nat Med 18, 1016–1018 (2012). https://doi.org/10.1038/nm.2855

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2855

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing