Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A viral strategy to ambush tumors

Nature Medicine volume 17, pages 784–785 (2011)Cite this article

Subjects

A new combinatorial approach harnesses the power of immuno- and virotherapy in a vesicular stomatitis virus (VSV) vector carrying a cDNA library that expresses normal human prostate antigens, thus providing proof of principle that this vaccine can induce prostate tumor rejection in mice (pages 854–859). This strategy might bypass many of the issues associated with conventional cancer immuno- or virotherapy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Kottke et al.5 propose a model in which murine TC2 prostate cancer can be treated in vivo by the intravenous administration of oncolytic VSV encoding a cDNA library derived from normal human prostate.

Renee Lucas

References

  1. Chiocca, E.A. Curr. Opin. Mol. Ther. 10, 38–45 (2008).

    PubMed  Google Scholar 

  2. Prestwich, R.J. et al. Hum. Gene Ther. 20, 1119–1132 (2009).

    Article  CAS  Google Scholar 

  3. Koos, D. et al. Cell. Immunol. 263, 138–147 (2010).

    Article  CAS  Google Scholar 

  4. Stratton, M.R., Campbell, P.J. & Futreal, P.A. Nature 458, 719–724 (2009).

    Article  CAS  Google Scholar 

  5. Kottke, T. et al. Nat. Med. 17, 854–859 (2011).

    Article  CAS  Google Scholar 

  6. Daniels, G.A. et al. Nat. Biotechnol. 22, 1125–1132 (2004).

    Article  CAS  Google Scholar 

  7. Kottke, T. et al. Cancer Res. 69, 7767–7774 (2009).

    Article  CAS  Google Scholar 

  8. Kalluri, R. & Weinberg, R.A. J. Clin. Invest. 119, 1420–1428 (2009).

    Article  CAS  Google Scholar 

  9. Santisteban, M. et al. Cancer Res. 69, 2887–2895 (2009).

    Article  CAS  Google Scholar 

  10. Phillips, H.S. et al. Cancer Cell 9, 157–173 (2006).

    Article  CAS  Google Scholar 

  11. Qiao, J. et al. Nat. Med. 14, 37–44 (2008).

    Article  CAS  Google Scholar 

  12. Seymour, L.W., Cawood, R. & Fisher, K.D. Curr. Opin. Mol. Ther. 10, 321–322 (2008).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurological Surgery, Christopher Alvarez-Breckenridge and E. Antonio Chiocca are at the Dardinger Neuro-oncology Center, James Cancer Hospital and Solove Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA.,

    Christopher Alvarez-Breckenridge & E Antonio Chiocca

Authors
  1. Christopher Alvarez-Breckenridge
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E Antonio Chiocca
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E Antonio Chiocca.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Alvarez-Breckenridge, C., Chiocca, E. A viral strategy to ambush tumors. Nat Med 17, 784–785 (2011). https://doi.org/10.1038/nm0711-784

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0711-784

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing