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A new treasure in the breast cancer gene hunt

Nature Medicine volume 17, pages 422–423 (2011)Cite this article

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A new potential breast cancer oncogene, ZNF703, has been identified in the chromosomal region 8p12 in humans, which is commonly amplified in an aggressive subtype of breast cancer. ZNF703 is a transcriptional repressor and regulates many genes that are involved in multiple aspects of the cancer phenotype, such as increased proliferation, invasion and an altered balance of progenitor stem cells.

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Figure 1: ZNF703 influences multiple aspects of the cancer phenotype.

Marina Corral

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Authors and Affiliations

  1. Paul Spellman is at the Lawrence Berkeley National Laboratory, Berkeley, California, USA, and the US National Cancer Institute, Bethesda, Maryland, USA.,

    Paul Spellman

  2. Joe Gray is at Oregon Health and Science University, Portland, Oregon, USA.,

    Joe Gray

Authors
  1. Paul Spellman
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  2. Joe Gray
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Correspondence to Joe Gray.

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The authors declare no competing financial interests.

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Spellman, P., Gray, J. A new treasure in the breast cancer gene hunt. Nat Med 17, 422–423 (2011). https://doi.org/10.1038/nm0411-422

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