Retinoic acid receptors inhibit chondrogenesis, but their ability to block the cartilaginous scaffold of heterotopic endochondral ossification has not been explored. A study in mice shows that agonists of retinoic acid receptor-γ potently inhibit heterotopic endochondral ossification, suggesting therapeutic potential in people with this condition (pages 454–460).
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Kaplan, F., Shore, E. Derailing heterotopic ossification and RARing to go. Nat Med 17, 420–421 (2011). https://doi.org/10.1038/nm0411-420
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DOI: https://doi.org/10.1038/nm0411-420
