Ephrin-B2 is required for the formation of blood and lymphatic vessels, but the mechanism has been enigmatic. Two independent studies show that ephrin-B2 controls the internalization and signaling of two types of vascular endothelial growth factor (VEGF) receptors—thereby regulating VEGF-induced angiogenesis in normal and pathological conditions.
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Germain, S., Eichmann, A. VEGF and ephrin-B2: a bloody duo. Nat Med 16, 752–754 (2010). https://doi.org/10.1038/nm0710-752
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DOI: https://doi.org/10.1038/nm0710-752
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