There is no cure for osteoarthritis—the most common disease of the joints. By piecing together the molecular events that drive the progression of this debilitating disease, recent studies published in Nature Medicine put hypoxia-inducible factor-2α (HIF-2α) in the driver's seat, opening up new avenues for early detection and treatment (pages 678–686 and 687–693).
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Acknowledgements
Supported by the VA Research Service and US National Institutes of Health grants PAGO7996, AR1067966, 5T32AR007608.
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Husa, M., Liu-Bryan, R. & Terkeltaub, R. Shifting HIFs in osteoarthritis. Nat Med 16, 641–644 (2010). https://doi.org/10.1038/nm0610-641
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DOI: https://doi.org/10.1038/nm0610-641
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