The US Food and Drug Administration approved the first-ever vaccine to treat cancer on 29 April. After a three-year battle with the regulatory agency and three phase 3 trials, the treatment—called Provenge, by Seattle-based Dendreon—extended median survival time in men with advanced prostate cancer by more than four months.

The success of Provenge could herald many more therapeutic vaccine treatments for everything from brain tumors to renal cancer, says Joseph Pantginis, a biotech analyst with Roth Capital Partners in New York. “It finally breaks the glass ceiling after years of skepticism and many failures in the cancer immunotherapy space.”

Here are ten promising cancer vaccines currently in mid- to late-stage development.