The enemy within: dormant retroviruses awaken

Journal name:
Nature Medicine
Volume:
16,
Pages:
517–518
Year published:
DOI:
doi:10.1038/nm0510-517

Mammalian genomes harbor regulatory elements from ancient retroviral infections. These retroviral remnants are normally silenced by DNA methylation—but this can change. Reactivation of one such element triggers the expression of a nearby oncogene during the development of Hodgkin's lymphoma (571–579).

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Affiliations

  1. Michael E. Engel is in the Department of Pediatrics, the Department of Cancer Biology, the Monroe Carell Jr. Children's Hospital and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

  2. Scott W. Hiebert is in the Department of Pediatrics and the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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The authors declare no competing financial interests.

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