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Endoplasmic reticulum stress and atherosclerosis

Nature Medicine volume 16, pages 396–399 (2010)Cite this article

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Abstract

Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are strongly influenced by pathways that lie at the interface of chronic inflammation and nutrient metabolism. Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications.

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Figure 1: Canonical unfolded protein response.
Figure 2: Macrophage ER stress in inflammation and apoptosis.

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Acknowledgements

Studies in the Hotamisligil laboratory are supported by grants from the US National Institutes of Health, the American Diabetes Association and the Juvenile Diabetes Research Foundation. I am grateful to the students and fellows who contributed to the studies in my group over the years. My special thanks to E. Erbay for critical discussions, thoughtful comments and help in preparing the manuscript. I regret the possible omission of relevant references to important work by my colleagues owing to space limitations.

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Authors and Affiliations

  1. Gökhan S. Hotamisligil is in the Departments of Genetics and Complex Diseases and Nutrition and the Broad Institute of Massachusetts Institute of Technology and Harvard, Harvard School of Public Health, Boston, Massachusetts, USA.,

    Gökhan S Hotamisligil

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  1. Gökhan S Hotamisligil
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Correspondence to Gökhan S Hotamisligil.

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Competing interests

G.S. is on the Scientific Advisory Board and is a shareholder of Syndexa Pharmaceuticals.

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Hotamisligil, G. Endoplasmic reticulum stress and atherosclerosis. Nat Med 16, 396–399 (2010). https://doi.org/10.1038/nm0410-396

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