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Lipids control mucus production in cystic fibrosis

Altered lipid metabolism underlies the production of excess mucus in a mouse model of cystic fibrosis (313–318). The findings point to the nuclear receptor peroxisome proliferator–activated receptor-γ (PPAR-γ) as a potential therapeutic target in this disease.

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Figure 1: The 15-keto-PGE2–PPAR-γ system regulates mucus production in cystic fibrosis.

Katie Vicari

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Correspondence to Erich Gulbins.

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Gulbins, E. Lipids control mucus production in cystic fibrosis. Nat Med 16, 267–268 (2010). https://doi.org/10.1038/nm0310-267

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  • DOI: https://doi.org/10.1038/nm0310-267

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