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Degeneration and repair in central nervous system disease

Nature Medicine volume 16, pages 1205–1209 (2010)Cite this article

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Abstract

Divergent disease triggers in neurodegeneration may induce convergent endogenous pathways in neuronal, glial and vascular elements as the central nervous system (CNS) attempts to compensate, remodel and recover. Dissecting these multicellular mechanisms and the integrative responses in cerebral blood flow and metabolism may allow us to understand the balance between injury and repair, validate new targets and define therapeutic time windows for neurodegeneration.

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Figure 1: Endogenous responses, cofactors and therapeutic time windows in neurodegeneration.

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Acknowledgements

The author apologizes to colleagues whose important work could not be directly cited. Because of space limitations, mostly review articles were used as starting points for discussion. Many thanks to B. Bacskai, D. Selkoe, B. Hyman, M. Schwarzschild and M.M. Ning for helpful discussions; and F. Beal, D. Cleveland, E. Mandelkow, W. Robberecht and all participants in the Herrenhausen Symposium on Neurodegeneration for a wonderful educational experience.

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Authors and Affiliations

  1. Departments of Neurology and Radiology, Eng H. Lo is at the Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.,

    Eng H Lo

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Correspondence to Eng H Lo.

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Lo, E. Degeneration and repair in central nervous system disease. Nat Med 16, 1205–1209 (2010). https://doi.org/10.1038/nm.2226

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