Brief Communication abstract
Nature Medicine 15, 876 - 878 (2009)
Published online: 20 July 2009 | Corrected online: 5 November 2009 | doi:10.1038/nm.1989
There is a Corrigendum (November 2009) associated with this Brief Communication.
Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells
Natalie A Hutnick1, Diane G Carnathan1, Sheri A Dubey2, George Makedonas1, Kara S Cox2, Lisa Kierstead2, Sarah J Ratcliffe3, Michael N Robertson2, Danilo R Casimiro2, Hildegund C J Ertl4 & Michael R Betts1
The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5–HIV-1 vectors in the Merck STEP trial remain unclear. We find that Ad5 serostatus does not predict Ad5-specific CD4+ T cell frequency, and we did not observe durable significant differences in Ad5-specific CD4+ T cells between Ad5-seropositive and Ad5-seronegative subjects after vaccination. These findings indicate no causative role for Ad5-specific CD4+ T cells in increasing HIV-1 susceptibility in the STEP trial.
- Department of Microbiology and Center for AIDS Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
- Merck Research Laboratories, West Point, Pennsylvania, USA.
- Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
- The Wistar Institute, Philadelphia, Pennsylvania, USA.
Correspondence to: Michael R Betts1 e-mail: betts@mail.med.upenn.edu
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