1. Brent H. Koehn and Stephen P. Schoenberger are in the Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.

Correspondence to: Stephen P. Schoenberger¹ e-mail: sps@liai.org

Abstract

Manipulation of cell renewal pathways creates T memory stem cells that can generate a sustained and targeted immune response. These findings have broad implications for vaccine development and immunotherapy (pages 808–813).

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