Brief Communication abstract
Nature Medicine 15, 741 - 745 (2009)
Published online: 5 June 2009 | Corrected online: 4 September 2009 | doi:10.1038/nm.1997
There is an Erratum (September 2009) associated with this Brief Communication.
GOAT links dietary lipids with the endocrine control of energy balance
Henriette Kirchner1,2,4, Jesus A Gutierrez3,4, Patricia J Solenberg3,4, Paul T Pfluger1, Traci A Czyzyk3, Jill A Willency3, Annette Schürmann2, Hans-Georg Joost2, Ronald J Jandacek1, John E Hale3, Mark L Heiman3 & Matthias H Tschöp1,2
Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.
- Departments of Psychiatry and Medicine, Obesity Research Centre & Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
- Department of Pharmacology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.
- Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA.
- These authors contributed equally to this work.
Correspondence to: Matthias H Tschöp1,2 e-mail: matthias.tschoep@uc.edu.
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