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Nature Medicine 15, 615 (2009)
doi:10.1038/nm0609-615

Compound clamps down on prostate cancer

Most individuals with metastatic prostate cancer develop resistance to standard treatments, which antagonize the action of growth-promoting androgens. The origins of such 'castration-resistant' tumors have been traced in part to increases in expression of the androgen receptor and to shortcomings in receptor-blocking drugs, which can even act as agonists.

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