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Nature Medicine 15, 490–491 (1 May 2009) | doi:10.1038/nm0509-490
Chaos in the embryo
Abstract
It's amazing that any of us has made it this far, let alone that any of our children are healthy. It's well known that high rates of abnormal chromosome segregation (nondisjunction) occur in human female meiosis, leading to chromosomal aneuploidy and early pregnancy loss or offspring with developmental disorders.
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