Brief Communication abstract
Nature Medicine 15, 377 - 379 (2009)
Published online: 15 March 2009 | doi:10.1038/nm.1940
Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury
David J Loane1, Ana Pocivavsek1, Charbel E-H Moussa1, Rachel Thompson1, Yasuji Matsuoka2, Alan I Faden1, G William Rebeck1 & Mark P Burns1
Amyloid-
(A) peptides, found in Alzheimer's disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either - or 
-secretase, enzymes required for production of A from amyloid precursor protein (APP), can ameliorate motor and cognitive deficits and reduce cell loss after experimental TBI in mice. Thus, APP secretases are promising targets for treatment of TBI.
- Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA.
- Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.
Correspondence to: Mark P Burns1 e-mail: mpb37@georgetown.edu
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