News and Views
Nature Medicine 15, 247 - 249 (2009)
doi:10.1038/nm0309-247
Intolerant of glucose and gasping for oxygen
Fiona M Gribble1
- Fiona M. Gribble is at the Cambridge Institute for Medical Research and Department of Clinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK. e-mail: fmg23@cam.ac.uk
Abstract
Findings in knockout mice indicate that hypoxia-sensitive pathways modulate the glucose-sensing machinery of pancreatic beta cells. Conditions that mimic hypoxia severely impair glucose-stimulated insulin release.
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