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Nature Medicine 15, 1130 (2009)
doi:10.1038/nm1009-1130
Biomarkers for Alzheimer's disease: the dilemma of silent disease
Alzheimer's disease researchers have homed in on a few molecules in the cerebrospinal fluid (CSF) that may help diagnose Alzheimer's disease before clear-cut symptoms emerge. Niklas Mattsson et al.1 have now conducted the largest trial of such biomarkers in 1,583 subjects—including 750 people with mild cognitive impairment who were followed for at least two years after measurement of the markers.
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