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γ-secretase inhibitors: Notch so bad

Nature Medicine volume 15, pages 20–21 (2009)Cite this article

γ-secretase inhibitors inhibit Notch, a transmembrane receptor that drives many cases of T cell acute lymphoblastic leukemia—but there are safety concerns with such drugs. Combining these inhibitors with glucocorticoids could provide a more effective and safer approach (pages 50–58).

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Figure 1: Combined treatment of NOTCH-positive T-ALL with a γ-secretase inhibitor and dexamethasone.

Katie Ris-Vicari

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Authors and Affiliations

  1. Gerard C. Grosveld is at St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105-3678, USA. gerard.grosveld@stjude.org,

    Gerard C Grosveld

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  1. Gerard C Grosveld
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Grosveld, G. γ-secretase inhibitors: Notch so bad. Nat Med 15, 20–21 (2009). https://doi.org/10.1038/nm0109-20

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