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Nature Medicine 14, 909 - 910 (2008)
doi:10.1038/nm0908-909
Live longer with LAMP-2
Paul Saftig1 & Eeva-Liisa Eskelinen1
- Paul Saftig is at the Biochemical Institute at the University Kiel, Olshausenstrasse 40, D-24098 Kiel, Germany.
e-mail: psaftig@biochem.uni-kiel.de - Eeva-Liisa Eskelinen is at the Division of Biochemistry at the University of Helsinki, PO Box 56, FIN-00014 Helsinki, Finland.
e-mail: eeva-liisa.eskelinen@helsinki.fi
Abstract
Upregulation of a protein involved in lysosomal degradation of proteins helps stave off some of the cellular decline observed with aging. The findings could lead to new approaches to fend off age-related disease or even extend lifespan (pages 959–965).
"Enjoy life. There's plenty of time to be dead.
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RESEARCH
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3The EMBO Journal Article (08 Apr 2009)
Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptorThe EMBO Journal Article (02 Jan 2003)
