1. Samir M. Parikh is in the Department of Medicine Beth, Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
2. S. Ananth Karumanchi is in the Departments of Medicine and Obstetrics and Gynecology and the Howard Hughes Medical Institute at Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
   e-mail: sananth@bidmc.harvard.edu

Abstract

Women with pre-eclampsia, a potentially deadly complication of pregnancy, produce agonistic autoantibodies against angiotensin receptor-1, a transmembrane protein that regulates blood pressure. Findings in mice suggest how these antibodies might help trigger the condition (pages 855–862).

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