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Between Bedside and Bench
Nature Medicine 14, 721 - 722 (2008)
doi:10.1038/nm0708-721
Bench to Bedside: Soothing the seizures of children
Beat Lutz1 & Krisztina Monory1
Abstract
Endocannabinoids are versatile molecules, regulating a variety of functions in the body. Daniele Piomelli explores how recent clinical trials testing rimonabant, an inhibitor of endocannabinoid signaling, for weight loss emerged from studies of individuals with schizophrenia; such trials have spurred basic research into how endocannabinoids affect both energy use and mood. Beat Lutz and Krisztina Monory examine how rimonabant might prove useful for preventing the development of adult epilepsy in response to fever-induced seizures in infants and young children.
Seizures induced by fever affect 3–5% of infants, with potential long-term consequences1. Evidence is accumulating that prolonged or focal febrile seizures in children between the ages of six months and five years are associated with the development of intractable temporal lobe epilepsy.
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