Clearance of platelets by the liver can help counteract the dangerous blood coagulation that can occur during sepsis. The mechanism involves clearance of platelets through the liver's Ashwell receptor, which binds to platelet glycoproteins altered by sepsis-causing bacteria (pages 648–655).
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van 't Veer, C., van der Poll, T. Keeping blood clots at bay in sepsis. Nat Med 14, 606–608 (2008). https://doi.org/10.1038/nm0608-606
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DOI: https://doi.org/10.1038/nm0608-606
