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Nature Medicine 14, 603 - 604 (2008)
doi:10.1038/nm0608-603
Multiple layers of metabolism
Mukesh K Jain1
- Mukesh K. Jain is at the Case Cardiovascular Research Institute, Case Western Reserve University, Iris & Bert Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106, USA. e-mail: mukesh.jain2@case.edu
Abstract
A new layer of gene regulation emerges for the metabolic regulator peroxisome proliferator–activated receptor-
(PPAR-). A team consisting of a Krüppel-like transcription factor and a SUMO protease regulate the expression of PPAR- target genes, thereby controlling energy metabolism (pages 656–666).
Cells need to finely tune gene expression to maintain homeostasis. Such control is achieved partly through the actions of sequence-specific transcription factors and associated coregulators1.
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