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From the following article

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

Edy Y Kim, John T Battaile, Anand C Patel, Yingjian You, Eugene Agapov, Mitchell H Grayson, Loralyn A Benoit, Derek E Byers, Yael Alevy, Jennifer Tucker, Suzanne Swanson, Rose Tidwell, Jeffrey W Tyner, Jeffrey D Morton, Mario Castro, Deepika Polineni, G Alexander Patterson, Reto A Schwendener, John D Allard, Gary Peltz & Michael J Holtzman

Nature medicine 14, 633 - 640 (2008) Published online: 18 May 2008

doi:10.1038/nm1770

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

IL-13–producing macrophages drive chronic airway disease after viral infection.

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Figure 2

Activated NKT cells are required for chronic IL-13 production by macrophages in the lung after viral infection.

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Figure 3

Direct interaction between lung NKT cells and macrophages activates IL-13 production by macrophages.

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Figure 4

NKT cells drive IL-13R expression to upregulate IL-13 production and alternative activation of macrophages after viral infection.

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Figure 5

Increased IL-13–producing macrophages and Valpha24-expressing NKT cells in humans with COPD and mucous cell metaplasia.

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Figure 6

Schematic showing an NKT cell–macrophage immune axis leading to chronic airway disease after viral infection.

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