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Technical Report
Nature Medicine 14, 579-584 (1 May 2008) | doi:10.1038/nm1708;
Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing
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Abstract
PCR is widely employed as the initial DNA amplification step for genetic testing. However, a key limitation of PCR-based methods is the inability to selectively amplify low levels of mutations in a wild-type background.
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