Getting embryonic stem cell therapy right - p467

doi:10.1038/nm0508-467

Embryonic stem cell therapy may soon enter clinical trials. The US Food and Drug Administration (FDA) will need to provide clear guidance on how it will regulate such trials and ensure that politics will not cloud the regulatory process.

Abstract - | Full Text - Getting embryonic stem cell therapy right | PDF (88 KB) - Getting embryonic stem cell therapy right

Haunted house - p468

doi:10.1038/nm0508-468a

The use of ghostwriters to pen scientific papers is nothing new, but if we want to get rid of them, stricter authorship rules may not be sufficient for a successful exorcism.

Abstract - | Full Text - Haunted house | PDF (51 KB) - Haunted house

Translational moves - p468

doi:10.1038/nm0508-468b

In this issue of the journal, we introduce some changes to underscore our long-standing interest in translational research.

Abstract - | Full Text - Translational moves | PDF (51 KB) - Translational moves

Return to the basics might breathe life into HIV vaccine pipeline - p469

Roxanne Khamsi

doi:10.1038/nm0508-469

Full Text - Return to the basics might breathe life into HIV vaccine pipeline | PDF (211 KB) - Return to the basics might breathe life into HIV vaccine pipeline

Etiology of eating disorders explored as patience for a cure thins - p470

Trisha Gura

doi:10.1038/nm0508-470

Full Text - Etiology of eating disorders explored as patience for a cure thins | PDF (209 KB) - Etiology of eating disorders explored as patience for a cure thins

Cancer clues fetched from canines - p471

Vicki Brower

doi:10.1038/nm0508-471a

Full Text - Cancer clues fetched from canines | PDF (151 KB) - Cancer clues fetched from canines

Scaled-up self-experimentation proposed - p471

Laura Spinney

doi:10.1038/nm0508-471b

Full Text - Scaled-up self-experimentation proposed | PDF (151 KB) - Scaled-up self-experimentation proposed

Harsh spotlight falls on Vytorin - p471

Meredith Wadman

doi:10.1038/nm0508-471c

Full Text - Harsh spotlight falls on Vytorin | PDF (151 KB) - Harsh spotlight falls on Vytorin

Straight talk with... Maria Freire - pp472 - 473

doi:10.1038/nm0508-472

Today, the practice of moving technologies from the lab to the marketplace is commonplace. But when Maria Freire began dabbling in the process a quarter-century ago, it had only just started receiving serious attention from the US government. As former head of the Office of Technology Transfer at the US National Institutes of Health (NIH), and more recently as chief executive officer and president of the Global Alliance for TB Drug Development (TB Alliance), Freire helped commercialize numerous new health technologies. This past March, she became president of the Albert and Mary Lasker Foundation, which each year awards the nation's most distinguished honors for science, often dubbed 'America's Nobels'. She spoke with Alisa Opar about her previous work advancing biomedical research and her new role at the foundation.

Abstract - | Full Text - Straight talk with... Maria Freire | PDF (305 KB) - Straight talk with... Maria Freire

Toaster oven helps researchers toy with microfluidics - p474

Alan Dove

doi:10.1038/nm0508-474

Full Text - Toaster oven helps researchers toy with microfluidics | PDF (236 KB) - Toaster oven helps researchers toy with microfluidics

News in brief: headlines from the past month - pp475 - 476

doi:10.1038/nm0508-475

Full Text - News in brief: headlines from the past month | PDF (1,069 KB) - News in brief: headlines from the past month

Hungry for sleep - pp477 - 480

Cassandra Willyard

doi:10.1038/nm0508-477

For many years, epidemiologists have linked sleep deprivation to poor health. Now, even as the average amount of shuteye people get continues to diminish, new evidence from biological research helps explain how missing out on sleep might contribute to obesity and diabetes. Cassandra Willyard asks what happens when we ignore the sandman.

Abstract - | Full Text - Hungry for sleep | PDF (547 KB) - Hungry for sleep

Progress in therapy: the delicate balance - p481

Jesse Roth reviews Prescribing by Numbers: Drugs and the Definition of Disease by Jeremy A Greene

doi:10.1038/nm0508-481

Full Text - Progress in therapy: the delicate balance | PDF (87 KB) - Progress in therapy: the delicate balance

Assessing fetal nerve cell grafts in Parkinson's disease - pp483 - 485

Heiko Braak & Kelly Del Tredici

doi:10.1038/nm1768

Three postmortem studies examine long-term fetal transplants in subjects with advanced Parkinson's disease. The findings—such as the development of parkinsonian pathology in some transplanted neurons—underscore the limitations of this approach.

Abstract - | Full Text - Assessing fetal nerve cell grafts in Parkinson's disease | PDF (1,713 KB) - Assessing fetal nerve cell grafts in Parkinson's disease

See also: Brief Communication by Li et al. | Brief Communication by Kordower et al. | Brief Communication by Mendez et al.

-adrenergic signaling in heart failure—adapt or die - pp485 - 487

Thomas Eschenhagen

doi:10.1038/nm0508-485

About 25% of the African-American population carries a gene variant that seems to protect against heart failure. The findings may have implications for the use of -blockers (pages 510–517).

Abstract - | Full Text - -adrenergic signaling in heart failure—adapt or die | PDF (248 KB) - -adrenergic signaling in heart failure—adapt or die

See also: Article by Liggett et al.

Dust mites' dirty dealings with dendritic cells - pp487 - 488

Dean Sheppard

doi:10.1038/nm0508-487

Allergens stimulate lymphocytes to become factories for secreted proteins that cause organ dysfunction in allergic diseases. Allergens are now shown to target dendritic cells, the cells responsible for processing and presenting antigens to T cells (pages 565–573).

Abstract - | Full Text - Dust mites' dirty dealings with dendritic cells | PDF (598 KB) - Dust mites' dirty dealings with dendritic cells

See also: Article by Krishnamoorthy et al.

A shot in the arm for mast cells - pp489 - 490

Bali Pulendran & Santa J Ono

doi:10.1038/nm0508-489

The search is on for for vaccine adjuvants that boost the innate immune response and complement existing adjuvants. Mast cell activators may be one option (pages 536–541).

Abstract - | Full Text - A shot in the arm for mast cells | PDF (2,049 KB) - A shot in the arm for mast cells

See also: Article by McLachlan et al.

Community Corner - p491

doi:10.1038/nm0508-491

Full Text - Community Corner | PDF (254 KB) - Community Corner

Research Highlights - pp492 - 493

doi:10.1038/nm0508-492

Full Text - Research Highlights | PDF (169 KB) - Research Highlights

Bedside to bench: Interfering with leukemic stem cells - pp494 - 495

Daniela S Krause & Richard A Van Etten

doi:10.1038/nm0508-494

Kinase inhibitors such as imatinib (Gleevec) have improved the outlook for many people with chronic myeloid leukemia and related blood disorders. But such drugs do not target the leukemia stem cell population and may not be curative. Krause and Van Etten discuss several clinical studies that suggest that interferon- may provide a solution by selectively eliminating leukemic stem cells—although only more basic research will tell us whether this is true and how it may happen.

Abstract - | Full Text - Bedside to benchInterfering with leukemic stem cells | PDF (94 KB) - Bedside to benchInterfering with leukemic stem cells

Bench to bedside: BRCA: From therapeutic target to therapeutic shield - pp495 - 496

Neil P Shah

doi:10.1038/nm0508-495

Three studies examine how resistance to chemotherapy develops in cancers deficient in BRCA1 and BRCA2. The mechanism involves restoration of BRCA1 and BRCA2 activity. Shah examines the implications for the clinic, such as the potential value of continuing treatment with cisplatin and similar agents even after drug resistance develops.

Abstract - | Full Text - Bench to bedsideBRCA: From therapeutic target to therapeutic shield | PDF (136 KB) - Bench to bedsideBRCA: From therapeutic target to therapeutic shield

A new penumbra: transitioning from injury into repair after stroke - pp497 - 500

Eng H Lo

doi:10.1038/nm1735

Abstract - | Full Text - A new penumbra: transitioning from injury into repair after stroke | PDF (328 KB) - A new penumbra: transitioning from injury into repair after stroke

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation - pp501 - 503

Jia-Yi Li, Elisabet Englund, Janice L Holton, Denis Soulet, Peter Hagell, Andrew J Lees, Tammaryn Lashley, Niall P Quinn, Stig Rehncrona, Anders Björklund, Håkan Widner, Tamas Revesz, Olle Lindvall & Patrik Brundin

doi:10.1038/nm1746

Abstract - | Full Text - Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation | PDF (840 KB) - Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation | Supplementary information

See also: News and Views by Braak & Del Tredici | Brief Communication by Kordower et al. | Brief Communication by Mendez et al.

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease - pp504 - 506

Jeffrey H Kordower, Yaping Chu, Robert A Hauser, Thomas B Freeman & C Warren Olanow

doi:10.1038/nm1747

Abstract - | Full Text - Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease | PDF (819 KB) - Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease | Supplementary information

See also: News and Views by Braak & Del Tredici | Brief Communication by Li et al. | Brief Communication by Mendez et al.

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years - pp507 - 509

Ivar Mendez, Angel Viñuela, Arnar Astradsson, Karim Mukhida, Penelope Hallett, Harold Robertson, Travis Tierney, Renn Holness, Alain Dagher, John Q Trojanowski & Ole Isacson

doi:10.1038/nm1752

Abstract - | Full Text - Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years | PDF (767 KB) - Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years | Supplementary information

See also: News and Views by Braak & Del Tredici | Brief Communication by Li et al. | Brief Communication by Kordower et al.

A GRK5 polymorphism that inhibits -adrenergic receptor signaling is protective in heart failure - pp510 - 517

Stephen B Liggett, Sharon Cresci, Reagan J Kelly, Faisal M Syed, Scot J Matkovich, Harvey S Hahn, Abhinav Diwan, Jeffrey S Martini, Li Sparks, Rohan R Parekh, John A Spertus, Walter J Koch, Sharon L R Kardia & Gerald W Dorn II

doi:10.1038/nm1750

Abstract - | Full Text - A GRK5 polymorphism that inhibits -adrenergic receptor signaling is protective in heart failure | PDF (410 KB) - A GRK5 polymorphism that inhibits -adrenergic receptor signaling is protective in heart failure | Supplementary information

See also: News and Views by Eschenhagen

Stromal gene expression predicts clinical outcome in breast cancer - pp518 - 527

Greg Finak, Nicholas Bertos, Francois Pepin, Svetlana Sadekova, Margarita Souleimanova, Hong Zhao, Haiying Chen, Gulbeyaz Omeroglu, Sarkis Meterissian, Atilla Omeroglu, Michael Hallett & Morag Park

doi:10.1038/nm1764

Abstract - | Full Text - Stromal gene expression predicts clinical outcome in breast cancer | PDF (867 KB) - Stromal gene expression predicts clinical outcome in breast cancer | Supplementary information

CD3-specific antibody–induced immune tolerance involves transforming growth factor- from phagocytes digesting apoptotic T cells - pp528 - 535

Sylvain Perruche, Pin Zhang, Yongzhong Liu, Philippe Saas, Jeffrey A Bluestone & WanJun Chen

doi:10.1038/nm1749

Abstract - | Full Text - CD3-specific antibody–induced immune tolerance involves transforming growth factor- from phagocytes digesting apoptotic T cells | PDF (996 KB) - CD3-specific antibody–induced immune tolerance involves transforming growth factor- from phagocytes digesting apoptotic T cells | Supplementary information

Mast cell activators: a new class of highly effective vaccine adjuvants - pp536 - 541

James B McLachlan, Christopher P Shelburne, Justin P Hart, Salvatore V Pizzo, Rajen Goyal, Rhea Brooking-Dixon, Herman F Staats & Soman N Abraham

doi:10.1038/nm1757

Abstract - | Full Text - Mast cell activators: a new class of highly effective vaccine adjuvants | PDF (447 KB) - Mast cell activators: a new class of highly effective vaccine adjuvants | Supplementary information

See also: News and Views by Pulendran & Ono

Drug-induced cure drives conversion to a stable and protective CD8⁺ T central memory response in chronic Chagas disease - pp542 - 550

Juan M Bustamante, Lisa M Bixby & Rick L Tarleton

doi:10.1038/nm1744

Abstract - | Full Text - Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease | PDF (1,485 KB) - Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease | Supplementary information

Functional roles for C5a receptors in sepsis - pp551 - 557

Daniel Rittirsch, Michael A Flierl, Brian A Nadeau, Danielle E Day, Markus Huber-Lang, Charles R Mackay, Firas S Zetoune, Norma P Gerard, Katherine Cianflone, Jörg Köhl, Craig Gerard, J Vidya Sarma & Peter A Ward

doi:10.1038/nm1753

Abstract - | Full Text - Functional roles for C5a receptors in sepsis | PDF (303 KB) - Functional roles for C5a receptors in sepsis | Supplementary information

Inhibition of pulmonary antibacterial defense by interferon- during recovery from influenza infection - pp558 - 564

Keer Sun & Dennis W Metzger

doi:10.1038/nm1765

Abstract - | Full Text - Inhibition of pulmonary antibacterial defense by interferon- during recovery from influenza infection | PDF (647 KB) - Inhibition of pulmonary antibacterial defense by interferon- during recovery from influenza infection | Supplementary information

Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma - pp565 - 573

Nandini Krishnamoorthy, Timothy B Oriss, Melissa Paglia, Mingjian Fei, Manohar Yarlagadda, Bart Vanhaesebroeck, Anuradha Ray & Prabir Ray

doi:10.1038/nm1766

Abstract - | Full Text - Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma | PDF (768 KB) - Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma | Supplementary information

See also: News and Views by Sheppard

Noninvasive in vivo imaging of pancreatic islet cell biology - pp574 - 578

Stephan Speier, Daniel Nyqvist, Over Cabrera, Jia Yu, R Damaris Molano, Antonello Pileggi, Tilo Moede, Martin Köhler, Johannes Wilbertz, Barbara Leibiger, Camillo Ricordi, Ingo B Leibiger, Alejandro Caicedo & Per-Olof Berggren

doi:10.1038/nm1701

First Paragraph - | Full Text - Noninvasive in vivo imaging of pancreatic islet cell biology | PDF (883 KB) - Noninvasive in vivo imaging of pancreatic islet cell biology | Supplementary information

Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing - pp579 - 584

Jin Li, Lilin Wang, Harvey Mamon, Matthew H Kulke, Ross Berbeco & G Mike Makrigiorgos

doi:10.1038/nm1708

First Paragraph - | Full Text - Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing | PDF (367 KB) - Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing | Supplementary information

Corrigendum: Protein kinase CK2 links extracellular growth factor signaling with the control of p27^Kip1 stability in the heart - p585

Ludger Hauck, Christoph Harms, Junfeng An, Jens Rohne, Karen Gertz, Rainer Dietz, Matthias Endres & Rüdiger von Harsdorf

doi:10.1038/nm0508-585a

Full Text - Corrigendum: Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart | PDF (52 KB) - Corrigendum: Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart

Corrigendum: Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability - p585

Christopher A Jones, Nyall R London, Haoyu Chen, Kye Won Park, Dominique Sauvaget, Rebecca A Stockton, Joshua D Wythe, Wonhee Suh, Frederic Larrieu-Lahargue, Yoh-suke Mukouyama, Per Lindblom, Pankaj Seth, Antonio Frias, Naoyuki Nishiya, Mark H Ginsberg, Holger Gerhardt, Kang Zhang & Dean Y Li

doi:10.1038/nm0508-585b

Full Text - Corrigendum: Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability | PDF (52 KB) - Corrigendum: Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

Erratum: Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy - p585

Pei-Lin Hsiung, Jonathan Hardy, Shai Friedland, Roy Soetikno, Christine B Du, Amy P Wu, Peyman Sahbaie, James M Crawford, Anson W Lowe, Christopher H Contag & Thomas D Wang

doi:10.1038/nm0508-585c

Full Text - Erratum: Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy | PDF (52 KB) - Erratum: Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy