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Brief Communication
Nature Medicine 14, 507 - 509 (2008)
Published online: 6 April 2008 | doi:10.1038/nm1752
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
Ivar Mendez1,5, Angel Viñuela2,5, Arnar Astradsson2, Karim Mukhida1, Penelope Hallett2, Harold Robertson1, Travis Tierney2, Renn Holness1, Alain Dagher3, John Q Trojanowski4 & Ole Isacson2
Abstract
Postmortem analysis of five subjects with Parkinson's disease 9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.
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