Access
To read this story in full you will need to login or make a payment (see right).
Brief Communication
Nature Medicine 14, 507 - 509 (2008)
Published online: 6 April 2008 | doi:10.1038/nm1752
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
Ivar Mendez1,5, Angel Viñuela2,5, Arnar Astradsson2, Karim Mukhida1, Penelope Hallett2, Harold Robertson1, Travis Tierney2, Renn Holness1, Alain Dagher3, John Q Trojanowski4 & Ole Isacson2
Abstract
Postmortem analysis of five subjects with Parkinson's disease 9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Assessing fetal nerve cell grafts in Parkinson's diseaseNature Medicine News and Views (01 May 2008)
Assessing fetal nerve cell grafts in Parkinson's diseaseNature Medicine News and Views (01 May 2008)
See all 6 matches for News And ViewsRESEARCH
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagationNature Medicine Brief Communication (01 May 2008)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPaseNature Genetics Letter (01 Oct 2006)
See all 49 matches for Research