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Brief Communication
Nature Medicine 14, 504 - 506 (2008)
Published online: 6 April 2008 | doi:10.1038/nm1747
Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
Jeffrey H Kordower1, Yaping Chu1, Robert A Hauser2, Thomas B Freeman3 & C Warren Olanow4
Abstract
Fourteen years after transplantation into the striatum of an individual with Parkinson's disease, grafted nigral neurons were found to have Lewy body–like inclusions that stained positively for 
-synuclein and ubiquitin and to have reduced immunostaining for dopamine transporter. These pathological changes suggest that Parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. These findings have implications for cell-based therapies and for understanding the cause of Parkinson's disease.
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